Neonatal Cholestasis… Neonatal Cholestasis- when to suspect 25 Feb 20214 Mar 2021 Neonatal cholestasis is defined as jaundice with high color urine staining diaper in an infant within first 3 months of life. The common causes of neonatal cholestasis are – 1) Extra…
Laboratory Tests… Antinuclear Antibody-ANA 18 Feb 202118 Feb 2021 Antinuclear antibodies(ANA) are autoantibodies which recognize cellular antigens found predominantly(although not exclusively), in the cell nucleus. A positive ANA of 1:160 or more is highly suggestive of autoimmune diseases such…
PEDIATRIC DRUG THERAPY… Proton Pump Inhibitors 14 Feb 202112 Feb 2021 Proton pump inhibitors (PPIs) are substituted 2-pyridyl methyl sulfinyl benzimidazoles that inhibit the final common pathway in gastric acid secretion in the apical membrane of parietal cells regardless of the…
THE EAR… Tympanometry 7 Feb 20214 Feb 2021 Tympanometry is a technique used to look at the function of the middle ear. It is NOT a hearing test. It is a test used together with otoscopy and audiometry…
Defects in Carbohydrate Metabolism… Galactosemia 4 Feb 20212 Feb 2021 Galactosemia is a rare autosomal recessive inborn error of galactose metabolism. Galactosemia should be suspected in a neonate who has persistent unexplained jaundice with poor feeding and weight gain. Such…
Human Immunodeficiency Virus(HIV)… Diagnosis of HIV infection in Infants and Children 31 Jan 202131 Jan 2021 Maternal HIV antibodies usually persist for nearly 9- 12 months in the infant. In some children, they may persist for as long as 18 months. Following table shows the various…
Breastfeeding… Feeding guidelines for infant born to HIV positive mother 28 Jan 202128 Jan 2021 Breastfeeding (BF) does carry a risk of transmission of HIV infection from HIV infected mothers to their infants. However, with use of maternal Anti Retro Viral (ARV) Drugs, the chances…
Human Immunodeficiency Virus(HIV)… ARV prophylaxis in Infant born to a HIV positive mother 24 Jan 202127 Jan 2021 Scenario 1: Infant ARV prophylaxis when mother has not been taking Nevirapine during pregnancy Infants are to be given daily Nevirapine (NVP) from birth for 6 weeks regardless of the mode…
Diseases of the Blood… Hemophagocytic Lymphohistiocytosis (HLH) 14 Jan 202111 Jan 2021 Hemophagocytic lymphohistiocytosis is a terminology that is being encountered frequently in the past few years. It is a pathological entity where uncontrolled inflammation results in activation of lymphocytes. Activated T…
Henoch Scholein Purpura… Henoch Scholein Purpura 10 Jan 202110 Jan 2021 It is the most common primary systemic vasculitis in children. Diagnosis requires the presence of purpura or petechiae with lower limb predominance with one of the following four- Abdominal pain Arthritis…