Diseases of the Blood… Megaloblastic anemia treatment pearls 11 Sep 20228 Sep 2022 Vitamin B12 supplementation The schedules and dosages of vitamin B12 treatment are widely variable and there is no consensus on it. The cause of megaloblastic anemia and the response to…
Diseases of the Blood… Biochemical markers of B12 deficiency 4 Sep 20224 Sep 2022 Previous Post : Vitamin B12 levels Serum Holo-Transcobalamin Vitamin B12 bound to Transcobalamin = Holo-TC Represents 10 -30% of total Vitamin B12 present in serum Cells take up Holo-TC via…
Diseases of the Blood… Vitamin B12 Levels 28 Aug 202228 Aug 2022 WHO DefinitionsVitamin B12 cut-offB12 adequacy> 221 pmol/LLow B12148 -221 pmol/LB12 deficiency< 148 pmol/L Pitfalls of Serum Vitamin B12 Neither sensitive, nor specificVitamin B12 levels mostly reflect the predominant but functionally…
Diseases of the Blood… Timing of G6PD Assay 24 Apr 2022 Previous post - Neonatal Jaundice & G6PD deficiency G6PD diagnosis deficiency testing is based on direct measurements of G6PD activity in a population of RBCs. In the setting of an…
Diseases of the Blood… Neonatal Jaundice and G6PD Deficiency 21 Apr 202224 Apr 2022 Previous post - G6PD Deficiency Anemia and jaundice are often first noted in the newborn period in individuals with severe G6PD deficiency (Class I variants). The degree of jaundice is…
Diseases of the Blood… G6PD DEFICIENCY 17 Apr 202224 Apr 2022 G6PD deficiency is an X-linked disorder. The presence of anemia will vary depending on the severity of deficiency in the affected cells. WHO classified it according to the magnitude of the enzyme deficiency and…
Diseases of the Blood… Hemophagocytic Lymphohistiocytosis (HLH) 14 Jan 202111 Jan 2021 Hemophagocytic lymphohistiocytosis is a terminology that is being encountered frequently in the past few years. It is a pathological entity where uncontrolled inflammation results in activation of lymphocytes. Activated T…
Diseases of the Blood… Iron chelation therapy in Thalassemia major 17 Dec 202016 Dec 2020 Continued from Previous Post on Assessment of Iron Overload in Thalassemia Goal of chelation therapy is to decrease tissue iron to a safe level and to minimise level of non-transferrin bound iron (NTBI)…
Diseases of the Blood… Assessment of iron overload in Thalassemia patients 13 Dec 202013 Dec 2020 An inevitable complication of regular blood transfusions in a Thalassemia major is iron overload. Assessment of iron overload by serum ferritin is widely used, relatively easy to perform and most acceptable, but…
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