PEDIATRIC DRUG THERAPY… Proton Pump Inhibitors 14 Feb 202112 Feb 2021 Proton pump inhibitors (PPIs) are substituted 2-pyridyl methyl sulfinyl benzimidazoles that inhibit the final common pathway in gastric acid secretion in the apical membrane of parietal cells regardless of the…
Human Immunodeficiency Virus(HIV)… ARV prophylaxis in Infant born to a HIV positive mother 24 Jan 202127 Jan 2021 Scenario 1: Infant ARV prophylaxis when mother has not been taking Nevirapine during pregnancy Infants are to be given daily Nevirapine (NVP) from birth for 6 weeks regardless of the mode…
PEDIATRIC DRUG THERAPY… Choosing a Topical Steroid 17 Jan 202116 Jan 2021 The prescribing physician should know about the classification of Topical steroids. GRADECLASSEXAMPLES1Very high potency Clobetasol propionate, Halobetasol prop2High potency Betamethasone dipropionate, Diflorasone 3Medium potency ointmentMometasone / Fluticasone ointments 4Medium potency creamsMometasone / Fluticasone creams 5Lower medium Hydrocortisone butyrate 0.1%6Low…
Anti-Epileptic Drugs… Valproate 5 Nov 2020 Valproate is a commonly used as well as abused anti-epileptic drug. It is a broad- spectrum anti-epileptic which means that it is effective in nearly all types of seizures viz-…
Dermatitis… Tacrolimus 24 Sep 202024 Sep 2020 Topical calcineurin inhibitors (Tacrolimus/Pimecrolimus) are complex macrolide compounds and selectively inhibit cytokine transcription in activated T-cells Tacrolimus is used in chronic extensive atopic dermatitis as steroid sparing agent. Unlike Topical steroids,…
PEDIATRIC DRUG THERAPY… Role of Honey in Common Cold 16 Jul 202015 Jul 2020 Honey can be a good option for treating cough in children ≥1 year with the common cold. The honey (2.5 to 5 mL) can be given straight or diluted in liquid (eg,…
Anti-histaminics… Antihistaminics in pediatric practice 15 Mar 202011 Mar 2020 Histamine influence immunoregulation of the acute and chronic inflammatory response through 4 different types of receptors, called H1, H2, H3, and H4. Drugs classified in the first generation of antihistamines (“classical” antihistamines) are classified as first generation, include chlorpheniramine, diphenhydramine, promethazine, and hydroxyzine. They are sedating and necessitate multiple daily doses because of relatively short half-lives. The second…
Anti-histaminics… Commonly used anti-histaminics 15 Mar 201911 Mar 2020 First-generation H(1)-antihistaminesBrand Name with ConcentrationOral dosesHydroxyzineSyrups Atarax, Hicope (10mg/5ml)Drops Atarax, Hicope (6mg/ml).Tab Atarax (10mg, 25mg)1-2 mg/kg/day q 6 hrly oral.(Lower doses for Rhinitis, Higher dose as anti-allergic) 6 months–6 years initially 5–15…
