Anti-histaminics… Antihistaminics in pediatric practice 15 Mar 202011 Mar 2020 Histamine influence immunoregulation of the acute and chronic inflammatory response through 4 different types of receptors, called H1, H2, H3, and H4. Drugs classified in the first generation of antihistamines (“classical” antihistamines) are classified as first generation, include chlorpheniramine, diphenhydramine, promethazine, and hydroxyzine. They are sedating and necessitate multiple daily doses because of relatively short half-lives. The second…
Anti-histaminics… Commonly used anti-histaminics 15 Mar 201911 Mar 2020 First-generation H(1)-antihistaminesBrand Name with ConcentrationOral dosesHydroxyzineSyrups Atarax, Hicope (10mg/5ml)Drops Atarax, Hicope (6mg/ml).Tab Atarax (10mg, 25mg)1-2 mg/kg/day q 6 hrly oral.(Lower doses for Rhinitis, Higher dose as anti-allergic) 6 months–6 years initially 5–15…
CENTRE FOR CHILD HEALTH, BLKMAX SUPER SPECIALITY HOSPITAL 