Commonly used anti-histaminics

First-generation H(1)-antihistaminesBrand Name with ConcentrationOral doses
HydroxyzineSyrups Atarax, Hicope (10mg/5ml)Drops Atarax, Hicope (6mg/ml).Tab Atarax (10mg, 25mg)1-2 mg/kg/day q 6 hrly oral.(Lower doses for Rhinitis, Higher dose as anti-allergic) 6 months–6 years initially 5–15 mg at night, increased if necessary to 50 mg daily in 3–4 divided doses. 6–12 years initially 15–25 mg at night, increased if necessary to 50–100 mg daily in 3–4 divided doses.12–18 years initially 25 mg at night, increased if necessary to 100 mg in 3–4 divided doses.
Promethazine hydrochlorideSyp Phenergan, Avomine(5mg/5ml) Tab (25 mg, 10 mg)0.2-0.5 mg/kg/dose 6-8H oral2-5 years 5 mg twice daily or 5–15 mg at night 5–10 years 5–10 mg twice daily or 10–25 mg at night10-18 years 10–20 mg 2–3 times daily or 25 mg at night increased to 25 mg twice daily if necessary.
ChlorpheniraminePresent in many decongestant Cough Syrups as 2 mg/5 ml and Drops 2 mg/ml (Tminic, Maxtra, Chericof, etc.)0.35 mg/kg/day q 6 hrly 2–6 years 1 mg q 6 hrly. 6–12 years 2 mg q 6 hrly>12 yrs – 4 mg q 6 hrly
Second-generation H(1)-antihistaminesBrand Name with ConcentrationOral doses
CetirizineSyp Relent, Cetzine (5mg/ 5ml),Tab Cetzine (5,10 mg)1–2 years 0.25 mg/kg twice daily 2–6 years 2.5 mg twice daily6–12 years 5 mg twice daily 12–18 years 10 mg once daily
LevocetirizineSyp Xyzal, Teczine (2.5mg/5ml)Tab 5mg6 mo – 6 yrs 1.25 mg daily6–12 years 2.5 mg twice daily >12 years 5 mg once daily
FexofenadineSyp Allegra, Histafree (30mg/5ml),Tab Allegra (120, 180mg)6mo- 2yrs 15 mg twice daily or 3mg/kg/day q 12 hrly2–12 years 30 mg twice daily 12–18 years 60mg BD, 120 mg once daily12–18 years 180 mg once daily
LoratadineSyp Lorfast (5 mg/5ml)Tab 10 mg2–6 years under 30 kg 5 mg once daily over 30 kg 10 mg once daily >6 yrs years 10 mg once daily

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