Author: Dr Amit Tyagi, Pediatrician

Consultant, Centre for Child Health, BLK Super Speciality Hospital.
Anti-histaminics…

Antihistaminics in pediatric practice

Histamine  influence  immunoregulation  of  the  acute  and chronic  inflammatory  response  through  4  different  types of  receptors,  called  H1,  H2,  H3,  and  H4. Drugs  classified  in the  first  generation  of  antihistamines  (“classical” antihistamines) are classified as first generation, include chlorpheniramine, diphenhydramine, promethazine, and hydroxyzine. They are sedating and necessitate multiple daily doses because of relatively short half-lives. The second…