Rheumatoid Factor

Rheumatoid Factor (RF) is an antibody(of IgM class) which is directed against the Fc portion of IgG. RF helps to classify patients with polyarticular juvenile idiopathic arthritis(PJIA) into RF positive and RF negative PJIA. 

ILAR (International League Against Rheumatism) criteria require 2 positive tests for RF 3 months apart as there can be transient appearance of RF with any intercurrent illness. RF is positive in over 60% of adult RA patients but is seen in only 5-10% of children with JIA. 

RF can also be positive in patients with Sjogren’s syndrome, sarcoidosis, infective endocarditis, tuberculosis. RF can be measured by latex agglutination, sheep RBC agglutination, nephelometry and ELISA. 

Anti-CCP (Anti-cyclic citrullinated peptide) antibody has a comparable sensitivity to RF in adults, with a higher specificity.

Post Pic Credits AICHRONICLES

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.