Role of Desmopressin in management of Enuresis

Previous Post: Management of Enuresis

Desmopressin, increases reabsorption of water by the distal convoluted tubule and collecting tubules in the kidney, thus reducing urine production. The response is dose-dependent. Desmopressin should be taken before sleep. Fluid intake must be avoided from 1 h before to 8 h after taking desmopressin, to prevent fluid overload and hyponatremia

  • Desmopressin is best for children with nocturnal polyuria and normal functional bladder capacity
  • Approximately 30 percent of patients achieve total dryness with perhaps another 40 percent exhibiting a significant decrease in night time wetting 
  • Relapse rate after discontinuation of desmopressin is high (60 to 70 percent)
  • Limit liquid intake one hour before to eight hours after administration of desmopressin
  • Desmopressin tablets 0.1/0.2 mg or (Minirin Melt* 60mcg/120 mcg) → 1 at bedtime

Post content drafted by Dr Kanav Anand. Pediatric Nephrologist. Sir Gangaram Hospital

Editorial comment

“Desmopressin is expensive. Most children are concerned about their bedwetting when visiting friends or a camp for few nights only. In such a situation, you may start medicating 2-3 days before the planned trip and stop it immediately after the child is back home. It is a good idea to test the efficacy of Desmopressin for few days before the trip to reassure the child.”

Next post : Role of Bedwetting Alarms in Enuresis

*Disclaimer “All product and company names are trademarks™ or registered® trademarks of their respective holders. Use of them does not imply any affiliation with or endorsement by them” 

Post Pic credit paediatricsandchildhealthjournal

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