Neonatal Jaundice and G6PD Deficiency

Previous post – G6PD Deficiency

Anemia and jaundice are often first noted in the newborn period in individuals with severe G6PD deficiency (Class I variants). The degree of jaundice is quite variable; in severe cases, there is a risk of bilirubin-induced neurologic dysfunction and kernicterus. 

In neonates with Class II or III G6PD-deficiency, jaundice is rarely present at birth. In some cases, a delayed peak of Jaundice can be seen till end of first week and in such cases prolonged jaundice is seen till end of second week. Jaundice is more prominent than anemia, which is rarely severe. 

So, a routine testing for G6PD deficiency should be performed in all neonates with hyperbilirubinemia or as a part of routine new born screening on cord blood samples.

Practice points

  • G6PD test done during neonatal period are only screening tests as definitive Quantitative assay are best done after age of 3 months.
  • Sample for G6PD screening should be processed within 4 hours of collection, as a delay can alter results.

LIST OF DRUGS CONTRAINDICATED IN G6PD DEFICIENCY

READ ALL SECTIONS ON G6PD DEFICIENCY

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